astigmatism

Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

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Study Counts

Type	Study_count
Total_Studies	180
interventional	153
Observational	26
Registry	1

Studies over Time by Start Date

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Interventional Trials

Intervention Type

intervention_type	Study_Count
Device	108
Procedure	28
Device|Procedure	8
Device|Other	3
Diagnostic Test	2
Other	2
Behavioral	1
Device|placebo	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country	Study_Count
United States	55
NA	30
United Kingdom	11
Austria	7
China	5
Mexico	5
Spain	4
Canada	3
Egypt	3
Germany	3
Korea, Republic of	3
Netherlands	3
Brazil	2
Iran, Islamic Republic of	2
Japan	2
United States|Canada	2
Austria|France|Germany	1
China|India	1
Colombia	1
Czech Republic	1
Denmark	1
France|Germany|Spain	1
Greece	1
Iraq	1
Malaysia	1
Mexico|Philippines	1
New Zealand	1
Sweden	1
United States|Australia	1

Sites per Study

Site_count	Study_Count
1	118
2	11
3	4
4	4
5	2
6	2
7	1
8	2
10	1
12	2
13	1
14	1
17	1
18	1
20	1
23	1

Phase

Phase	Study_Count
N/A	131
Phase 4	16
Phase 3	3
Phase 1/Phase 2	2
Phase 2	1

Number of Arms

Number_of_Arms	Count_of_Studies
1	35
2	90
3	12
4	3
6	3
12	2
19	1
NA	7

Enrollment Metrics by Phase

Measure	N.A	Phase.1.Phase.2	Phase.2	Phase.3	Phase.4
Min.	4.0000	30.0	40	35.00	18.0000
1st Qu.	36.5000	37.5	40	38.75	40.0000
Median	60.0000	45.0	40	42.50	52.5000
Mean	110.2901	45.0	40	42.50	63.8125
3rd Qu.	120.0000	52.5	40	46.25	61.5000
Max.	1100.0000	60.0	40	50.00	198.0000

Trial Group Type

group_type	Group_Count
Active Comparator	149
Experimental	133
Other	36
NA	7
No Intervention	3
Sham Comparator	2
Placebo Comparator	1

Intervention Model

intervention_model	Study_Count
Parallel Assignment	63
Single Group Assignment	50
Crossover Assignment	39
NA	1

Primary Purpose

primary_purpose	Study_Count
Treatment	121
Other	11
Diagnostic	6
Supportive Care	5
NA	5
Basic Science	2
Device Feasibility	2
Health Services Research	1

Observational Studies

Studies by Country

Country	Study_Count
United States	13
NA	3
China	2
Austria	1
Belgium	1
Canada	1
Egypt	1
Germany	1
Korea, Republic of	1
Norway	1
Spain	1

Sites per Study

Site_count	Study_Count
1	26

Enrollment Metrics

Measure	Observational
Min	20.0
1st Qu	40.0
Median	56.5
Mean	332.0
3rd Qu	303.0
Max	4000.0

Observation Model

observational_model	Study_Count
Cohort	14
Case-Only	4
Case-Control	2
Other	2
NA	2
Case-Crossover	1
Case Control	1

Time Perspective

time_perspective	Study_Count
Prospective	18
Cross-Sectional	4
Retrospective	3
NA	1

Registries

Studies by Country

Country	Study_Count
Turkey	1

Sites per Study

Site_count	Study_Count
1	1

Enrollment Metrics

Measure	Registries
Min	62
1st Qu	62
Median	62
Mean	62
3rd Qu	62
Max	62

Registry Model

observational_model	Study_Count
Case-Control	1

Time Perspective

time_perspective	Study_Count
Prospective	1

Follow-up

target_duration	Study_Count
30 Months	1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03392532	Comparison of Two Silicone Hydrogel Toric Contact Lenses	https://ClinicalTrials.gov/show/NCT03392532	Completed	Alcon Research	2018-01-26
NCT03350503	AcrySof IQ Toric A-Code Post-Market Clinical Study	https://ClinicalTrials.gov/show/NCT03350503	Active, not recruiting	Alcon Research	2019-05-23
NCT03819842	Evaluating the Need for the Pseudophakic Intraoperative Abberrometry in Toric IOL Implantation	https://ClinicalTrials.gov/show/NCT03819842	Completed	Alterman, Modi, & Wolter Ophthalmic Physicians & Surgeons	2019-01-14
NCT03313921	The MORE Study: Manifest vs. Online Refraction Evaluation	https://ClinicalTrials.gov/show/NCT03313921	Active, not recruiting	UMC Utrecht	2019-07-24
NCT03291873	Topography-Guided Customized PRK Versus Q-value Adjusted PRK in Correction of Myopia With or Without Astigmatism	https://ClinicalTrials.gov/show/NCT03291873	Completed	Kasr El Aini Hospital	2019-06-25
NCT03242486	Clinical Evaluation of Toric Intraocular Lens	https://ClinicalTrials.gov/show/NCT03242486	Completed	Nidek Co. LTD.	2017-05-31
NCT03202485	Comparison Between TICL and ICL+AK for High Myopic Astigmatism	https://ClinicalTrials.gov/show/NCT03202485	Completed	Wenzhou Medical University	2015-03-02
NCT03140046	Visual Outcomes of Topography Guided Photorefractive Keratectomy (PRK) for Treatment of Patients With Irregular Cornea	https://ClinicalTrials.gov/show/NCT03140046	Completed	Assiut University	2018-03-01
NCT03134248	Bilateral Dispensing Study of MyDay Toric, 1-day Acuvue Moist for Astigmatism, and Dailies Aquacomfort Plus Toric Lenses	https://ClinicalTrials.gov/show/NCT03134248	Completed	Coopervision, Inc.	2017-04-12
NCT03085901	Comparison of Clinical Outcomes of Toric Intraocular Lens	https://ClinicalTrials.gov/show/NCT03085901	Completed	Samsung Medical Center	2016-07-31
NCT03082599	Symfony Toric Intraocular Lens Visual Outcomes	https://ClinicalTrials.gov/show/NCT03082599	Completed	Carolina Eyecare Physicians, LLC	2018-04-03
NCT03063164	A Comparison of LASIK Outcomes Using Two Femtosecond Lasers	https://ClinicalTrials.gov/show/NCT03063164	Recruiting	Stanford University	2020-12-31
NCT03054649	ClarVista HARMONI Toric Trial With Intraoperative Exchange	https://ClinicalTrials.gov/show/NCT03054649	Completed	ClarVista Medical	2017-07-18
NCT03006458	A Clinical Comparison of 2 Multifocal Toric XR (Extended Range) Contact Lenses	https://ClinicalTrials.gov/show/NCT03006458	Completed	Coopervision, Inc.	2017-04-06
NCT02950545	Evaluating and Improving Functional Driving Vision of Patients With Astigmatism: Phase 3	https://ClinicalTrials.gov/show/NCT02950545	Completed	University of Virginia	2017-02-01
NCT02939001	Evaluating the Effect of Laser Vision Surgery, Phakic Intraocular Lens Implantation, Cataract Surgery, and Pupil Dilation on the Iris Recognition Scanner Function of Smartphone	https://ClinicalTrials.gov/show/NCT02939001	Completed	Yonsei University	2017-03-24
NCT02921412	Performance of Fanfilcon A Toric Lenses After at Least One Month Wearing Enfilcon A Toric Lenses	https://ClinicalTrials.gov/show/NCT02921412	Completed	Coopervision, Inc.	2017-02-01
NCT02847169	Clinical Performance of Toric Hydrogel Contact Lenses Following One Week of Daily Wear	https://ClinicalTrials.gov/show/NCT02847169	Completed	Coopervision, Inc.	2016-11-30
NCT02801006	The Clinical Study of Silicone Hydrogel Daily Disposable Stenfilcon A Toric Lens	https://ClinicalTrials.gov/show/NCT02801006	Completed	Coopervision, Inc.	2016-06-30
NCT02763124	Pseudophakic Astigmatic Reduction With Verion-LenSx Arcuate Incisions	https://ClinicalTrials.gov/show/NCT02763124	Completed	Gainesville Eye Associates	2016-10-31
NCT02675751	Prospective S&E Study of Wavefront-guided PRK for Myopia With iDesign Advanced Wavescan Studioâ„¢ System and Star S4 IRâ„¢	https://ClinicalTrials.gov/show/NCT02675751	Completed	Abbott Medical Optics	2018-07-27
NCT02649842	Post-Approval Study of the TECNIS® Toric Extended Cylinder Range Intraocular Lens (IOL)	https://ClinicalTrials.gov/show/NCT02649842	Completed	Abbott Medical Optics	2018-08-27
NCT02625220	Dispensing Evaluation of Investigational Contact Lenses	https://ClinicalTrials.gov/show/NCT02625220	Completed	Johnson & Johnson Vision Care, Inc.	2015-11-30
NCT02624791	Evaluating and Improving Functional Driving Vision of Patients With Astigmatism	https://ClinicalTrials.gov/show/NCT02624791	Completed	University of Virginia	2013-01-31
NCT02565537	High Resolution Wavefront-guided vs. Wavefront Optimized LASIK	https://ClinicalTrials.gov/show/NCT02565537	Active, not recruiting	Stanford University	2022-01-31
NCT03398109	Effectiveness of Toric Intraocular Lenses for Treating Corneal Astigmatism in Patients With Cataract and Previous DALK	https://ClinicalTrials.gov/show/NCT03398109	Completed	Fondazione G.B. Bietti, IRCCS	2017-06-29
NCT02551796	Early Changes Among FLEx, LASIK and FS-LASIK	https://ClinicalTrials.gov/show/NCT02551796	Completed	Sun Yat-sen University	2016-04-30
NCT02550353	Changes Between Lenticule Extraction and Femtosecond Laser-assisted Laser in Situ Keratomileusis	https://ClinicalTrials.gov/show/NCT02550353	Completed	Sun Yat-sen University	2016-03-31
NCT02540785	Early Changes Between Lenticule Extraction and Small-Incision Lenticule Extraction	https://ClinicalTrials.gov/show/NCT02540785	Completed	Sun Yat-sen University	2014-12-31
NCT02513745	Conventional Surgery vs. Verion/VerifEye	https://ClinicalTrials.gov/show/NCT02513745	Completed	Carolina Eyecare Physicians, LLC	2017-05-05
NCT02444923	Scleral Versus Corneal RGP Contact Lenses in Irregular Cornea Disorders	https://ClinicalTrials.gov/show/NCT02444923	Completed	London South Bank University	2019-01-29
NCT02430428	Correction of Myopia Wtih or Without Astigmatism Using the VisuMaxâ„¢ Femtosecond Laser	https://ClinicalTrials.gov/show/NCT02430428	Completed	Carl Zeiss Meditec, Inc.	2017-10-31
NCT02423109	Bilateral Dispensing Study of Fanfilcon A Toric Versus Enfilcon A Toric Lenses	https://ClinicalTrials.gov/show/NCT02423109	Completed	Coopervision, Inc.	2016-01-31
NCT02410824	Bilateral Dispensing Clinical Trial of Stenfilcon A Against Etafilcon A for Astigmatism	https://ClinicalTrials.gov/show/NCT02410824	Completed	Coopervision, Inc.	2015-06-30
NCT02370953	VERION Versus Conventional, Manual Ink-marking in Toric IOL Implantation	https://ClinicalTrials.gov/show/NCT02370953	Completed	Maastricht University Medical Center	2016-01-31
NCT02356692	Clinical Comfort Evaluation of Two Marketed Spherical Contact Lenses	https://ClinicalTrials.gov/show/NCT02356692	Completed	Coopervision, Inc.	2012-05-31
NCT02248766	Clinical Performance of Habitual Wearers of Avaira Toric When Refitted With Clariti Toric Lenses	https://ClinicalTrials.gov/show/NCT02248766	Completed	Coopervision, Inc.	2014-10-31
NCT02193178	Multicenter Dispensing Study of Biofinity Toric Made-To-Order Lenses in Extended Power Ranges	https://ClinicalTrials.gov/show/NCT02193178	Completed	Coopervision, Inc.	2016-04-30
NCT02185105	Clinical Validation of Biofinity Toric MTO (Made To Order) Lenses	https://ClinicalTrials.gov/show/NCT02185105	Completed	Coopervision, Inc.	2014-06-30
NCT02176343	Retrospective / Prospective Clinical Study of AcrySof® IQ ReSTOR® +2.5 D Multifocal Toric Intraocular Lenses	https://ClinicalTrials.gov/show/NCT02176343	Completed	Alcon Research	2014-08-22
NCT02155270	Impact of a Corneal Pre-cut on Wound Architecture and Astigmatism in Cataract Surgery - a Pilot Study	https://ClinicalTrials.gov/show/NCT02155270	Completed	Vienna Institute for Research in Ocular Surgery	2015-08-31
NCT02142361	Clinical Performance of Habitual Hydrogel vs. Silicone Hydrogel Toric Contact Lenses	https://ClinicalTrials.gov/show/NCT02142361	Completed	Coopervision, Inc.	2014-06-30
NCT02103309	Comparative Evaluation of Contact Lens Centering of DAILIES® AquaComfort Plus® Versus 1-DAY ACUVUE® MOIST® in Japan	https://ClinicalTrials.gov/show/NCT02103309	Completed	Alcon Research	2013-11-30
NCT02100410	On-Eye Evaluation of Contact Lens Axis Location	https://ClinicalTrials.gov/show/NCT02100410	Completed	Alcon Research	2013-04-30
NCT02091934	Wavefront-guided PRK vs Wavefront-optimized PRK	https://ClinicalTrials.gov/show/NCT02091934	Active, not recruiting	Stanford University	2017-12-31
NCT02071771	Visual Assessment of DAILIES® AquaComfort Plus® for Astigmatism as Compared to 1-DAY ACUVUE® MOIST® for Astigmatism	https://ClinicalTrials.gov/show/NCT02071771	Completed	Alcon Research	2014-09-30
NCT01293240	Prospective Study of Lens Performance of a Monthly Replacement Lens at Two Weeks and Four Weeks	https://ClinicalTrials.gov/show/NCT01293240	Completed	Alcon Research	2011-04-30
NCT01279031	Randomized Comparison of the Abbott WHITESTAR Signature System With Ellips Tranversal Ultrasound vs. the Alcon Infiniti With the Ozil Torsional Handpiece in Phacoemulsification: A Contralaterally-Controlled Trial	https://ClinicalTrials.gov/show/NCT01279031	Completed	Innovative Medical	2012-01-31
NCT02053688	Evaluation Study on Corneal Lens for Vision Correction	https://ClinicalTrials.gov/show/NCT02053688	Completed	FORSIGHT Vision3	2013-11-30
NCT02040129	Reduction of Corneal Astigmatism With Toric Intraocular Lens Implantation in Congenital Cataract	https://ClinicalTrials.gov/show/NCT02040129	Completed	Kyungpook National University Hospital	2009-01-31
NCT01995435	Refraction Determination Analysis	https://ClinicalTrials.gov/show/NCT01995435	Completed	Lee, Steven, M.D.	2015-06-30
NCT01988415	New Treatment Algorithm to Reduce Spherical Aberration After LASIK Correction for Myopia	https://ClinicalTrials.gov/show/NCT01988415	Completed	Abbott Medical Optics	2014-07-31
NCT01965288	Clinical Performance of Biofinity Toric Versus Air Optix for Astigmatism	https://ClinicalTrials.gov/show/NCT01965288	Completed	Coopervision, Inc.	2013-12-31
NCT01912781	Safety and Efficacy Evaluation of a New Contact Lens Disinfecting Solution in Gas Permeable Contact Lens Wearers	https://ClinicalTrials.gov/show/NCT01912781	Completed	Alcon Research	2014-05-31
NCT01912768	Safety and Efficacy Evaluation of a New Contact Lens Disinfecting Solution in Soft Contact Lens Wearers	https://ClinicalTrials.gov/show/NCT01912768	Completed	Alcon Research	2014-05-31
NCT01885780	Prospective Evaluation of the Effectiveness of the Femtosecond Laser-assisted Refractive Astigmatic Keratotomy.	https://ClinicalTrials.gov/show/NCT01885780	Completed	Technolas Perfect Vision GmbH	2014-03-31
NCT01858701	Visual Performance Investigation of Two Toric Soft Contact Lenses	https://ClinicalTrials.gov/show/NCT01858701	Completed	Alcon Research	2013-10-31
NCT01857102	Toric Eye Strain and Stability Study	https://ClinicalTrials.gov/show/NCT01857102	Completed	Johnson & Johnson Vision Care, Inc.	2014-06-30
NCT01778998	Impact of Incision Size and Architecture on Wound Stability and Astigmatism in Cataract Surgery: an Exploratory Study	https://ClinicalTrials.gov/show/NCT01778998	Completed	Vienna Institute for Research in Ocular Surgery	2013-09-30
NCT01763151	Comparison of Toric IOL Implantation and Opposite Clear Corneal Incision During Cataract Surgery to Correct Corneal Astigmatism	https://ClinicalTrials.gov/show/NCT01763151	Completed	Vienna Institute for Research in Ocular Surgery	2012-08-31
NCT01752218	A Study to Address Precision and Refractive Predictability of Femtosecond Laser-assisted Astigmatic Keratotomy Following the Cataract Surgery	https://ClinicalTrials.gov/show/NCT01752218	Completed	Technolas Perfect Vision GmbH	2014-04-30
NCT01699750	Comparative In-Vivo Wetting Characteristics of Silicone Hydrogel Materials With Selected Lens Care Systems	https://ClinicalTrials.gov/show/NCT01699750	Completed	Alcon Research	2013-11-30
NCT01699087	A Safety and Effectiveness Study of PRK Using the ALLEGRETTO WAVE® EYE-Q Excimer Laser System	https://ClinicalTrials.gov/show/NCT01699087	Completed	Alcon Research	2015-07-31
NCT01675492	Safety and Effectiveness of Wavefront-guided LASIK for the Correction of Mixed Astigmatism	https://ClinicalTrials.gov/show/NCT01675492	Completed	Abbott Medical Optics	2016-11-22
NCT01673503	A Prospective Study of Femtosecond Laser Intracorneal Lensectomi	https://ClinicalTrials.gov/show/NCT01673503	Completed	Odense University Hospital	NA
NCT01636167	Construction of Computerized Intraoperative Keratometer and Experimental Study	https://ClinicalTrials.gov/show/NCT01636167	Completed	Wenzhou Medical University	2011-12-31
NCT01629693	Clinical Evaluation of Two Monthly Replacement Silicone Hydrogel Contact Lenses	https://ClinicalTrials.gov/show/NCT01629693	Completed	Alcon Research	2013-11-30
NCT01579045	Effect of Head and Gaze Position on Soft Toric Contact Lens Performance	https://ClinicalTrials.gov/show/NCT01579045	Completed	Johnson & Johnson Vision Care, Inc.	2013-03-31
NCT01552876	Comparative Clinical Evaluation of Soft Toric Lens Designs	https://ClinicalTrials.gov/show/NCT01552876	Completed	Johnson & Johnson Vision Care, Inc.	2012-04-30
NCT01496066	Calhoun Vision Light Adjustable Lens (LAL) in Subjects With Pre-Existing Corneal Astigmatism	https://ClinicalTrials.gov/show/NCT01496066	Completed	Calhoun Vision, Inc.	2016-06-30
NCT01461811	Prospective Study of an Investigational Toric Soft Contact Lens	https://ClinicalTrials.gov/show/NCT01461811	Completed	Alcon Research	2012-04-30
NCT01454843	LASIK Using the Alcon Allegretto Wavefront-Guided Excimer Laser vs AMO Visx Wavefront-Guided Excimer Laser	https://ClinicalTrials.gov/show/NCT01454843	Active, not recruiting	Stanford University	2021-12-31
NCT01362894	Clinical Comparison of Two Daily Disposable Toric Lenses	https://ClinicalTrials.gov/show/NCT01362894	Completed	Alcon Research	2011-08-31
NCT01348854	Safety and Effectiveness of Arcuate Incisions Performed With the iFS Femtosecond Laser System	https://ClinicalTrials.gov/show/NCT01348854	Completed	Abbott Medical Optics	2013-04-30
NCT04426175	Z8 OCT-controlled 2D vs 3D LASIK	https://ClinicalTrials.gov/show/NCT04426175	Completed	Zentrumsehstarke Hamburg	2020-04-23
NCT04345380	Rotational Stability of the Acrysof, Tecnis and Envista Intraocular Lenses	https://ClinicalTrials.gov/show/NCT04345380	Completed	Medical University of Vienna	2017-08-18
NCT04327518	Evaluation of the Rotational Stability of the Tecnis Toric II IOL	https://ClinicalTrials.gov/show/NCT04327518	Recruiting	Johnson & Johnson Surgical Vision, Inc.	2021-04-14
NCT04321226	Femtosecond Laser-assisted Astigmatism Treatment	https://ClinicalTrials.gov/show/NCT04321226	Active, not recruiting	Medical University of Vienna	2019-03-05
NCT04283149	Multicenter Clinical Trial of a Phakic Implantable Collamer® Lens (ICL)	https://ClinicalTrials.gov/show/NCT04283149	Recruiting	Staar Surgical Company	2021-01-01
NCT04208750	Clinical Investigation of the Vision-R800 Device.	https://ClinicalTrials.gov/show/NCT04208750	Recruiting	Indiana University	2020-11-01
NCT04111757	A Study With Technolas® TENEO 317 Model 2 Excimer Laser to Treat Participants With Myopia or Myopic Astigmatism	https://ClinicalTrials.gov/show/NCT04111757	Recruiting	Bausch & Lomb Incorporated	2021-02-28
NCT04072289	SMILE (Small Incision Lenticule Extraction) in the DoD (Department of Defense)	https://ClinicalTrials.gov/show/NCT04072289	Recruiting	United States Naval Medical Center, San Diego	2021-04-30
NCT04050605	Refitting Somofilcon A Toric Contact Lens Wearers Into Fanfilcon A Toric Lenses for 4-weeks of Wear	https://ClinicalTrials.gov/show/NCT04050605	Completed	Coopervision, Inc.	2019-08-16
NCT04016623	Clinical Evaluation of Invigor Toric 1-Day Contact Lenses	https://ClinicalTrials.gov/show/NCT04016623	Completed	Coopervision, Inc.	2019-05-15
NCT03947944	Clinical Outcomes of Small-incision Lenticule Extraction (SMILE) Using Vector Planning Method.	https://ClinicalTrials.gov/show/NCT03947944	Completed	Yonsei University	2019-05-07
NCT03929588	Study of a Hand-held Device Plus Mobile App Versus Standard Eye Care Devices in Measuring Refractive Error of the Eye	https://ClinicalTrials.gov/show/NCT03929588	Recruiting	EyeQue Corp.	2020-01-31
NCT03913338	Laser In-situ Keratomileusis With Crosslinking Compared to Conventional LASIK in Patients With High Myopia	https://ClinicalTrials.gov/show/NCT03913338	Completed	University Clinic Frankfurt	2018-07-03
NCT03861351	Non-comparative Trial Following Participants Implanted Bilaterally With Mini WELL Toric Ready Intraocular Lens for 6 Months After the Second Eye Implant (FUSION)	https://ClinicalTrials.gov/show/NCT03861351	Recruiting	SIFI SpA	2020-07-31
NCT03841253	Treatment of Vision Disturbances Due to Corneal Irregularities by Trans-epithelial Optical Phototherapeutic Keratectomy (TE-oPTK)	https://ClinicalTrials.gov/show/NCT03841253	Recruiting	London Vision Clinic	2021-06-01
NCT03791619	Post-Approval Study of the TECNIS SYMFONY® Toric Lenses	https://ClinicalTrials.gov/show/NCT03791619	Recruiting	Johnson & Johnson Surgical Vision, Inc.	2022-06-30
NCT03779503	Comparison of Two Daily Disposable Soft Contact Lenses	https://ClinicalTrials.gov/show/NCT03779503	Completed	Coopervision, Inc.	2019-08-26
NCT03735602	Neural Mechanisms Underlying Astigmatism	https://ClinicalTrials.gov/show/NCT03735602	Recruiting	Zhongshan Ophthalmic Center, Sun Yat-sen University	2021-03-31
NCT03728218	Visual Outcomes for Toric Efficacy Study	https://ClinicalTrials.gov/show/NCT03728218	Recruiting	University of Houston	2019-06-30
NCT03688672	Apioc Contact Lens Feasibility	https://ClinicalTrials.gov/show/NCT03688672	Recruiting	Lentechs, LLC	2019-06-30
NCT03684928	A Bilateral Dispensing Comparison of Comfilcon A Over Senofilcon C Contact Lenses	https://ClinicalTrials.gov/show/NCT03684928	Completed	Coopervision, Inc.	2018-12-14
NCT03681808	Evaluate the Safety and Effectiveness of the Biotrue ONEday for Astigmatism	https://ClinicalTrials.gov/show/NCT03681808	Completed	Bausch Health Americas, Inc.	2019-12-16
NCT03633851	Toric IOL vs Non-toric IOL With LRI for Corneal Astigmatism	https://ClinicalTrials.gov/show/NCT03633851	Recruiting	Ashford and St. Peter’s Hospitals NHS Trust	2019-08-31
NCT03610997	Photorefractive Keratectomy for Severe Anisometropia and Isoametropia Associated With Amblyopia	https://ClinicalTrials.gov/show/NCT03610997	Active, not recruiting	Baylor College of Medicine	2028-08-01
NCT03597906	Topography Guided LASIK by Different Protocols for Treatment of Astigmatism	https://ClinicalTrials.gov/show/NCT03597906	Completed	Cairo University	2019-11-15
NCT03578926	Performance of Two Toric Silicone Hydrogel Contact Lenses	https://ClinicalTrials.gov/show/NCT03578926	Completed	Coopervision, Inc.	2018-10-08
NCT03546647	Toric Contact Lens Performance Study	https://ClinicalTrials.gov/show/NCT03546647	Completed	University of Houston	2018-12-21
NCT03538964	Assessing the Astigmatism Reducing Effect With Toric IOLs in Eyeswith Low Astigmatism	https://ClinicalTrials.gov/show/NCT03538964	Recruiting	Vienna Institute for Research in Ocular Surgery	2020-05-02
NCT03519932	Comparison of Comfilcon A Toric Contact Lenses and Samfilcon A Toric Contact Lenses	https://ClinicalTrials.gov/show/NCT03519932	Completed	Coopervision, Inc.	2018-10-15
NCT03519282	Clinical Evaluation of Investigational Multifocal Toric Contact Lenses	https://ClinicalTrials.gov/show/NCT03519282	Completed	Coopervision, Inc.	2018-07-24
NCT03502863	Clinical Study to Evaluate Effectiveness of Digital Refraction	https://ClinicalTrials.gov/show/NCT03502863	Completed	Opternative	2018-07-06
NCT03418064	Performance of Toric Silicone Hydrogel Contact Lenses Following One Month of Daily Wear	https://ClinicalTrials.gov/show/NCT03418064	Completed	Coopervision, Inc.	2018-05-16
NCT01250964	Endothelial Cell Loss and Induced Astigmatism After Wound-directed and Wound-assisted IOL Injection	https://ClinicalTrials.gov/show/NCT01250964	Completed	University of North Carolina, Chapel Hill	2010-11-30
NCT01211535	Subjective Comfort With Multipurpose Care Solutions in Soft Contact Lens Wearers	https://ClinicalTrials.gov/show/NCT01211535	Completed	Alcon Research	2010-11-30
NCT01210820	Feasibility of iFSâ„¢ for Intrastromal Arcuate Keratotomy (ISAK) Procedures	https://ClinicalTrials.gov/show/NCT01210820	Completed	Abbott Medical Optics	2012-06-30
NCT01180998	Clinical Evaluation of Two Toric Contact Lenses in Current Non-toric Lens Users	https://ClinicalTrials.gov/show/NCT01180998	Completed	Johnson & Johnson Vision Care, Inc.	2010-10-01
NCT01140594	Wavefront-guided Photorefractive Keratectomy (PRK) Versus Wavefront-guided Lasik for Myopia	https://ClinicalTrials.gov/show/NCT01140594	Active, not recruiting	Stanford University	2021-12-31
NCT01140477	Toric Intraocular Lens Following Cataract Surgery	https://ClinicalTrials.gov/show/NCT01140477	Completed	Bausch & Lomb Incorporated	2011-12-31
NCT01135719	A Comparison of Fellow Eyes Undergoing LASIK or PRK With a Wavefront-guided Excimer Laser Versus a Wavefront-optimized Excimer Laser	https://ClinicalTrials.gov/show/NCT01135719	Active, not recruiting	Stanford University	2022-12-31
NCT01120782	Non-dispensing Study to Check Prescription Equivalence of Two Daily Disposable Toric Contact Lens Types	https://ClinicalTrials.gov/show/NCT01120782	Completed	Johnson & Johnson Vision Care, Inc.	2010-02-01
NCT01097525	Optical Quality, Threshold Target Identification, and Military Target Task Performance After Advanced Keratorefractive Surgery	https://ClinicalTrials.gov/show/NCT01097525	Completed	Fort Belvoir Community Hospital	2014-10-31
NCT01075542	Astigmatism Management in Cataract Surgery With the AcrySof Toric Intraocular Lens	https://ClinicalTrials.gov/show/NCT01075542	Completed	Maastricht University Medical Center	2012-10-31
NCT01070381	Daily Disposable Toric Comparative Trial in Europe	https://ClinicalTrials.gov/show/NCT01070381	Completed	Alcon Research	2010-03-31
NCT01055132	Dispensing Evaluation of New Daily Disposable Toric Soft Contact Lens.	https://ClinicalTrials.gov/show/NCT01055132	Completed	Johnson & Johnson Vision Care, Inc.	2010-02-28
NCT01045733	A Comparison of Corneal Aberrations in Subjects With Contralateral AcrySof IQ Toric Intraocular Lens (IOL) and AcrySof IQ IOL With Limbal Relaxing Incision (LRI)	https://ClinicalTrials.gov/show/NCT01045733	Completed	Alcon Research	2011-05-31
NCT01024855	Comparative Evaluation of Corneal Staining With Balafilcon A Lenses and Two Multi-Purpose Solutions	https://ClinicalTrials.gov/show/NCT01024855	Completed	Abbott Medical Optics	2009-06-30
NCT01018797	Intrastromal Corneal Ring for High Astigmatism on Postkeratoplasty	https://ClinicalTrials.gov/show/NCT01018797	Completed	Instituto de Olhos de Goiania	2009-07-31
NCT01007812	Clinical Comparison of Two Silicone Hydrogel Toric Lenses in the US	https://ClinicalTrials.gov/show/NCT01007812	Completed	Alcon Research	2009-11-30
NCT00978692	Toric Orthokeratology - Slowing Eye Elongation	https://ClinicalTrials.gov/show/NCT00978692	Completed	The Hong Kong Polytechnic University	2012-07-31
NCT00925886	Use of Toric Intraocular Lens to Neutralize Keratometric Astigmatism	https://ClinicalTrials.gov/show/NCT00925886	Completed	Asociación para Evitar la Ceguera en México	2009-03-31
NCT00876707	Wavefront Analyzes and Visual Performance of Three Multifocal Intra-ocular Lenses	https://ClinicalTrials.gov/show/NCT00876707	Completed	University of Sao Paulo	2009-11-30
NCT01432834	Efficacy of the Wavefront Optimized (WFO) Profile in Non-anterior Astigmatisms	https://ClinicalTrials.gov/show/NCT01432834	Completed	Democritus University of Thrace	2010-12-31
NCT00825513	Safety and Effectiveness of the Akreos Toric Intraocular Lens.	https://ClinicalTrials.gov/show/NCT00825513	Completed	Bausch & Lomb Incorporated	2012-03-31
NCT00821236	Contralateral Comparison of Three Excimer Laser Systems in Performing LASIK	https://ClinicalTrials.gov/show/NCT00821236	Completed	Durrie Vision	2010-02-28
NCT01809197	Silicone Hydrogel Contact Lens Clinical and Comfort Benefits With a Multi-Purpose Disinfecting Solution	https://ClinicalTrials.gov/show/NCT01809197	Completed	Alcon Research	2013-07-31
NCT03050697	Evaluation of the Safety and Performance of the HARMONI® Toric Lens	https://ClinicalTrials.gov/show/NCT03050697	Completed	ClarVista Medical	2017-06-07
NCT04418986	Incisional Correction of Corneal Astigmatism During Phacoemulsification	https://ClinicalTrials.gov/show/NCT04418986	Completed	Al-Rasheed University College	2019-09-30
NCT04210232	Post-market Study to Obtain Surgeon Feedback on Clinical Outcome in Eyes Implanted With TECNIS Toric II IOL	https://ClinicalTrials.gov/show/NCT04210232	Active, not recruiting	Johnson & Johnson Surgical Vision, Inc.	2021-02-28
NCT01207466	Evaluation of Two Daily Disposable Contact Lenses for Wearers With Astigmatism	https://ClinicalTrials.gov/show/NCT01207466	Completed	Alcon Research	2010-10-31
NCT00762502	Comparison of Senofilcon A Toric Lenses to Balafilcon A Toric Lenses Over Extended Wear Period	https://ClinicalTrials.gov/show/NCT00762502	Completed	Johnson & Johnson Vision Care, Inc.	2008-01-31
NCT00761826	Study of the MEL 80 Excimer Laser Using LASIK in the Treatment of Mixed Astigmatism	https://ClinicalTrials.gov/show/NCT00761826	Completed	Carl Zeiss Meditec, Inc.	2008-12-31
NCT00742950	Refractive Change Induced by 2.8-mm Corneal Incision	https://ClinicalTrials.gov/show/NCT00742950	Completed	Hospital Universitario Ramon y Cajal	2009-09-30
NCT00697190	Clinical Performance of Atypical Contact Lens Powers on Subjects With Astigmatism	https://ClinicalTrials.gov/show/NCT00697190	Completed	Johnson & Johnson Vision Care, Inc.	2008-09-30
NCT00663923	Comparison of Cross-cylinder and Conventional Photorefractive Keratectomy(PRK) in Correcting Medium-high Astigmatism	https://ClinicalTrials.gov/show/NCT00663923	Completed	Tabriz University	2009-06-30
NCT00658996	Product Performance of a Toric Contact Lens	https://ClinicalTrials.gov/show/NCT00658996	Completed	Bausch & Lomb Incorporated	2008-06-30
NCT00657670	Evaluation of Effectiveness of Correcting Refractive Error With Ready-made Spectacles	https://ClinicalTrials.gov/show/NCT00657670	Completed	Johns Hopkins University	2008-11-30
NCT00584831	Effect of Eye Movement on Toric Lens Orientation and Visual Acuity	https://ClinicalTrials.gov/show/NCT00584831	Completed	Johnson & Johnson Vision Care, Inc.	2008-02-29
NCT00584727	In-office Evaluation of Two Toric Soft Contact Lenses and a Spherical Soft Contact Lens	https://ClinicalTrials.gov/show/NCT00584727	Completed	Johnson & Johnson Vision Care, Inc.	2007-11-30
NCT00584220	Evaluation of Two Toric Soft Contact Lenses After Two Weeks of Wear	https://ClinicalTrials.gov/show/NCT00584220	Completed	Johnson & Johnson Vision Care, Inc.	2007-12-31
NCT00583908	Evaluation of Orientation and Visual Acuity of Four Toric Soft Contact Lenses When Head is Tilted at 90 Degrees	https://ClinicalTrials.gov/show/NCT00583908	Completed	Johnson & Johnson Vision Care, Inc.	2008-01-31
NCT00542581	Acrysof Toric SN60T3corneal Astigmatism Between 0.75 and 1.00 D.	https://ClinicalTrials.gov/show/NCT00542581	Completed	Medical University of South Carolina	2008-12-31
NCT00521833	Surgically Induced Astigmatism of Temporal Versus Nasal Clear Corneal Phacoemulsification	https://ClinicalTrials.gov/show/NCT00521833	Completed	Shahid Beheshti University of Medical Sciences	NA
NCT00366769	Evaluation of Outcomes Following LASIK Surgery Using CustomVue	https://ClinicalTrials.gov/show/NCT00366769	Completed	Medical University of South Carolina	NA
NCT00366743	Evaluation of Visual Outcomes After Myopic LASIK	https://ClinicalTrials.gov/show/NCT00366743	Completed	Medical University of South Carolina	NA
NCT00366574	Comparison of a Laser Keratome to a Mechanical Microkeratome	https://ClinicalTrials.gov/show/NCT00366574	Completed	Medical University of South Carolina	NA
NCT00365677	A Study to Investigate the Safety and Effectiveness of Aspheric Laser Refractive Surgery Treatments for Myopia	https://ClinicalTrials.gov/show/NCT00365677	Completed	Bausch & Lomb Incorporated	2006-03-31
NCT00365040	Customized PRK With Mitomycin Versus Customized Lasik for Myopic Astigmatism	https://ClinicalTrials.gov/show/NCT00365040	Completed	Federal University of São Paulo	NA
NCT00348205	A Study to Evaluate the Safety and Effectiveness of the Technols 217z Zyoptix System for Hyperopia	https://ClinicalTrials.gov/show/NCT00348205	Completed	Bausch & Lomb Incorporated	2009-01-31
NCT00000123	The Berkeley Orthokeratology Study	https://ClinicalTrials.gov/show/NCT00000123	Completed	National Eye Institute (NEI)	NA

Observational Studiess

#If less then 500 studies

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03299530	Accuracy of Corneal Astigmatism in Different Region Modes	https://ClinicalTrials.gov/show/NCT03299530	Recruiting	Wenzhou Medical University	2020-06-10
NCT03159780	Prevalence of Corneal Astigmatism Before Glaucoma Surgery in Chinese Patients With Primary Angle-closure Glaucoma	https://ClinicalTrials.gov/show/NCT03159780	Completed	Zhongshan Ophthalmic Center, Sun Yat-sen University	2017-08-31
NCT03097302	Tomographic Analysis of Anterior, Posterior, Total Corneal Refractive Power Changes After Laser-assisted Keratotomy	https://ClinicalTrials.gov/show/NCT03097302	Completed	University Clinic Frankfurt	2014-07-31
NCT02576483	An Evaluation of LASIK, SMILE and PRK Surgery in Physicians	https://ClinicalTrials.gov/show/NCT02576483	Recruiting	Stanford University	2025-01-31
NCT02203747	Patient Perception of Visual Distortions	https://ClinicalTrials.gov/show/NCT02203747	Completed	Abbott Medical Optics	2014-10-31
NCT02161263	Quality of Vision and Quality of Life With LASIK	https://ClinicalTrials.gov/show/NCT02161263	Active, not recruiting	Stanford University	2021-12-31
NCT02155959	Performance of a Single-piece Toric Acrylic Intraocular Lens	https://ClinicalTrials.gov/show/NCT02155959	Completed	Vienna Institute for Research in Ocular Surgery	2012-12-31
NCT02155556	Diurnal Changes of the Cornea - a Pilot Study	https://ClinicalTrials.gov/show/NCT02155556	Completed	Vienna Institute for Research in Ocular Surgery	2014-08-31
NCT01893671	Corneal Power, Astigmatism, and Aberration Changes After LASIK	https://ClinicalTrials.gov/show/NCT01893671	Completed	Oregon Health and Science University	2017-08-31
NCT01711190	Astigmatism Post-trabeculectomy	https://ClinicalTrials.gov/show/NCT01711190	Completed	Universitaire Ziekenhuizen Leuven	2012-11-30
NCT01601665	Post Approval Study of the AcrySof® IQ Toric Intraocular Lens (IOL) Models SN6AT6-SN6AT9	https://ClinicalTrials.gov/show/NCT01601665	Completed	Alcon Research	2015-07-31
NCT01365728	An Outcomes Study Comparing the Intralase FS 60 to the Intralase iFS When Performing LASIK Surgery for Nearsightedness	https://ClinicalTrials.gov/show/NCT01365728	Completed	Stanford University	2018-12-31
NCT04393740	Contribution of Posterior Corneal Astigmatism to Total Corneal Astigmatism in a Sample of Egyptian Population	https://ClinicalTrials.gov/show/NCT04393740	Recruiting	Cairo University	2020-07-15
NCT04387721	Influence of Residual Astigmatism on Visual Acuity in Patients Undergoing Cataract Surgery With Trifocal Intraocular Lens Implantation	https://ClinicalTrials.gov/show/NCT04387721	Recruiting	Clinica Oftalmologica TACIR	2020-03-01
NCT04297969	Hyperopia Detection GCK With Glow Fixation	https://ClinicalTrials.gov/show/NCT04297969	Completed	Alaska Blind Child Discovery	2019-11-06
NCT04251143	Dresden Corneal Disease and Treatment Study	https://ClinicalTrials.gov/show/NCT04251143	Recruiting	Technische Universität Dresden	2025-12-31
NCT04249505	Refractive Accuracy of “2WIN” and Portable Autorefractors	https://ClinicalTrials.gov/show/NCT04249505	Recruiting	Alaska Blind Child Discovery	2020-03-31
NCT01214863	AcrySof Toric Clinical Results	https://ClinicalTrials.gov/show/NCT01214863	Completed	Alcon Research	2008-04-30
NCT01138189	Wavefront-guided Versus Wavefront-optimized LASIK for Nearsightedness	https://ClinicalTrials.gov/show/NCT01138189	Active, not recruiting	Stanford University	2022-12-31
NCT00842231	Assessment of Visual Performance in Patients With Low Levels of Astigmatism	https://ClinicalTrials.gov/show/NCT00842231	Completed	Alcon Research	2009-03-31
NCT03162471	How Astigmatism Influences Corneal Biomechanics and Intraocular Pressure	https://ClinicalTrials.gov/show/NCT03162471	Completed	Medical Universtity of Lodz	2016-12-01
NCT02023619	Corneal Epithelial and Stromal Thickness Distribution in Keratoconus	https://ClinicalTrials.gov/show/NCT02023619	Completed	SynsLaser Kirurgi AS	2013-09-30
NCT01978106	Comparisons of the Astigmatic Power of Toric Intraocular Lens Using Three Toric Calculators: AcrySof, TECNIS, and iTrace Toric Calculator	https://ClinicalTrials.gov/show/NCT01978106	Completed	Yonsei University	2013-04-30
NCT00778570	Advanced Surface Ablation (ASA) vs Laser-Assisted In Situ Keratomileusis (LASIK)	https://ClinicalTrials.gov/show/NCT00778570	Recruiting	Ottawa Hospital Research Institute	2020-12-31
NCT00581659	Evaluation of the Bausch & Lomb PureVision Under Nighttime Driving Conditions	https://ClinicalTrials.gov/show/NCT00581659	Completed	University of Iowa	2008-10-31
NCT00818532	Corneal Astigmatism Measurement Study	https://ClinicalTrials.gov/show/NCT00818532	Completed	Alcon Research	2009-04-30

Registries

#If less then 500 registries

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT04432181	Comparison of Deviation Types Among Astigmatic Children With Or Without Amblyopia	https://ClinicalTrials.gov/show/NCT04432181	Completed	Sakarya University	2019-02-01